The McCoy lab studies mechanisms driving dryness and autoimmunity. We work to dissentangle the immunobiology of mesenchymal stromal cells as a targetable cell for therapeutic intervention. We model disease in 2d co-culture systems, organoids, microfluidics systems, and mice. Our goal is to identify novel MSC targets to treat autoimmunity and dryness. Another focus of the lab is to identify and understand novel autoantibodies in Sjogren’s disease. Our work is highly translational and we deployed the first study of marrow-derived MSCs to treat SjD and GvHD.
Our mission is to use collaboration & the unique strengths of our team members, we gain pathogenic insights into glandular immunobiology, improving quality of life & developing cures for patients with dryness & autoimmunity